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Orphanet Acute adrenal insufficiency Ovulation is the result of a maturation process that occurs in the hypothalamic-pituitary-ovarian (HPO) axis and is orchestrated by a neuroendocrine cae terminating in the ovaries. Acute adrenal insufficiency AAI is a rare but severe condition caused by a sudden defective production of adrenal steroids cortisol and aldosterone.
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